MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.

نویسندگان

  • Stephen A Kolodziej
  • Susan L Hockerman
  • Gary A DeCrescenzo
  • Joseph J McDonald
  • Debbie A Mischke
  • Grace E Munie
  • Theresa R Fletcher
  • Nathan Stehle
  • Craig Swearingen
  • Daniel P Becker
چکیده

A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 20 12  شماره 

صفحات  -

تاریخ انتشار 2010